@article{54891,
  author = {Liu Wu Austin RH Sturm JC. Loutherback K1 D{\textquoteright}Silva J},
  title = {Deterministic separation of cancer cells from blood at 10 mL/min.},
  abstract = { <p>Circulating tumor cells (CTCs) and circulating clusters of cancer and stromal cells have been identified in the blood of patients with malignant cancer and can be used as a diagnostic for disease severity, assess the efficacy of different treatment strategies and possibly determine the eventual location of metastatic invasions for possible treatment. There is thus a critical need to isolate, propagate and characterize viable CTCs and clusters of cancer cells with their associated stroma cells. Here, we present a microfluidic device for mL/min flow rate, continuous-flow capture of viable CTCs from blood using deterministic lateral displacement (DLD) arrays. We show here that a DLD array device can isolate CTCs from blood with capture efficiency greater than 85\% CTCs at volumetric flow rates of up to 10 mL/min with no effect on cell viability.</p> },
  year = {2012},
  journal = {AIP Adv. 2012 Dec;2(4):42107. Epub 2012 Oct 3.},
  url = {http://www.ncbi.nlm.nih.gov/pubmed/23112922},
  language = {eng},
}